Ontology highlight
ABSTRACT:
SUBMITTER: Duhamel S
PROVIDER: S-EPMC4934081 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Duhamel Stéphanie S Girondel Charlotte C Dorn Jonas F JF Tanguay Pierre-Luc PL Voisin Laure L Smits Ron R Maddox Paul S PS Meloche Sylvain S
Cell cycle (Georgetown, Tex.) 20160506 12
Aneuploidy is a common feature of human solid tumors and is often associated with poor prognosis. There is growing evidence that oncogenic signaling pathways, which are universally dysregulated in cancer, contribute to the promotion of aneuploidy. However, the mechanisms connecting signaling pathways to the execution of mitosis and cytokinesis are not well understood. Here, we show that hyperactivation of the ERK1/2 MAP kinase pathway in epithelial cells impairs cytokinesis, leading to polyploid ...[more]