Ontology highlight
ABSTRACT:
SUBMITTER: Pietrzak M
PROVIDER: S-EPMC4934664 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Pietrzak Maciej M Rempala Grzegorz A GA Nelson Peter T PT Hetman Michal M
Gene 20160320 1
A next generation bisulfite sequencing (NGBS) was used to study rDNA promoter methylation in human brain using postmortem samples of the parietal cortex. Qualitative analysis of patterns of CpG methylation was performed at the individual rDNA unit level. CpG site-specific differences in methylation frequency were observed with the core promoter harboring three out of four most methylated CpGs. Moreover, there was an overall trend towards co-methylation for all possible pairs of 26 CpG sites. The ...[more]