Ontology highlight
ABSTRACT:
SUBMITTER: Clausen BH
PROVIDER: S-EPMC4935869 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Clausen Bettina Hjelm BH Degn Matilda M Sivasaravanaparan Mithula M Fogtmann Torben T Andersen Maria Gammelstrup MG Trojanowsky Michelle D MD Gao Han H Hvidsten Svend S Baun Christina C Deierborg Tomas T Finsen Bente B Kristensen Bjarne Winther BW Bak Sara Thornby ST Meyer Morten M Lee Jae J Nedospasov Sergei A SA Brambilla Roberta R Lambertsen Kate Lykke KL
Scientific reports 20160707
Microglia are activated following cerebral ischemia and increase their production of the neuro- and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function of TNF from this cellular source in focal cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in which the TNF gene was deleted in cells of the myeloid lineage, including microglia. The deletion reduced secreted TNF levels in lipopolysaccharide-stimulated cultured primary microglia by ~93%. Furt ...[more]