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IL-17C is required for lethal inflammation during systemic fungal infection.

ABSTRACT: Within the interleukin-17 (IL-17) family of cytokines, IL-17A is known to be critical in the host defense against fungal infections; however, the function of the other IL-17 family members in anti-fungal immunity remains largely unknown. Here, we show that IL-17C expression was highly induced in kidney epithelial cells after fungal infection. Mice that lacked IL-17C exhibited increased survival and attenuated kidney tissue damage, although they had similar fungal loads. IL-17C deficiency resulted in decreased pro-inflammatory cytokine expression compared with wild-type control mice. Additionally, IL-17C directly acted on renal epithelial cells in vitro to promote pro-inflammatory cytokine production. Taken together, our data demonstrate that IL-17C is a critical factor that potentiates inflammatory responses and causes host injury during fungal infection.

SUBMITTER: Huang J

PROVIDER: S-EPMC4947823 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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IL-17C is required for lethal inflammation during systemic fungal infection.

Huang Jinling J Meng Shaoshuai S Hong Shanjuan S Lin Xin X Jin Wei W Dong Chen C

Cellular & molecular immunology 20150713 4

Within the interleukin-17 (IL-17) family of cytokines, IL-17A is known to be critical in the host defense against fungal infections; however, the function of the other IL-17 family members in anti-fungal immunity remains largely unknown. Here, we show that IL-17C expression was highly induced in kidney epithelial cells after fungal infection. Mice that lacked IL-17C exhibited increased survival and attenuated kidney tissue damage, although they had similar fungal loads. IL-17C deficiency resulte ...[more]

PMID: 26166766

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