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Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials.


ABSTRACT: A previous systematic review and meta-analysis reported that omega-3 fatty acids nutrition may reduce mortality in septic patients. As new randomized controlled trials began to accumulate, we conducted an update.A PubMed database was searched through Feb 2016, and randomized controlled trials comparing omega-3 fatty acids with control were selected by two reviewers independently.Eleven trials randomly assigning 808 patients were included in the present study. Using a fixed effects model, we found no significant effect of omega-3 fatty acids on overall mortality (risk ratio 0.84; 95 % confidence interval (CI): 0.67 to 1.05, P?=?0.12), or infectious complications (risk ratio 0.95; 95 % CI: 0.72 to 1.25, P?=?0.70). However, the duration of mechanical ventilation was markedly reduced by omega-3 fatty acids (weighted mean differences (WMD)?=?-3.82; 95 % CI: -4.61 to -3.04; P?

SUBMITTER: Tao W 

PROVIDER: S-EPMC4950703 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials.

Tao Wei W   Li Ping-Song PS   Shen Zhou Z   Shu Yu-Sheng YS   Liu Sen S  

BMC anesthesiology 20160718 1


<h4>Background</h4>A previous systematic review and meta-analysis reported that omega-3 fatty acids nutrition may reduce mortality in septic patients. As new randomized controlled trials began to accumulate, we conducted an update.<h4>Methods</h4>A PubMed database was searched through Feb 2016, and randomized controlled trials comparing omega-3 fatty acids with control were selected by two reviewers independently.<h4>Results</h4>Eleven trials randomly assigning 808 patients were included in the  ...[more]

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