Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.
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SUBMITTER: O'Brien JM
PROVIDER: S-EPMC4960908 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
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Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.
O'Brien Jason M JM Beal Marc A MA Yauk Carole L CL Marchetti Francesco F
Toxicological sciences : an official journal of the Society of Toxicology 20160513 2
Although many environmental agents are established male germ cell mutagens, few are known to induce mutations in spermatogonial stem cells. Stem cell mutations are of great concern because they result in a permanent increase in the number of mutations carried in sperm. We investigated mutation induction during mouse spermatogenesis following exposure to benzo(a)pyrene (BaP). MutaMouse males were given 0, 12.5, 25, 50, or 100 mg/kg bw/day BaP for 28 days by oral gavage. Germ cells were collected ...[more]
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