Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.
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ABSTRACT:
SUBMITTER: Baldo A
PROVIDER: S-EPMC4963060 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
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Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.
Baldo Aline A Galanis Evanthia E Tangy Frédéric F Herman Philippe P
Human vaccines & immunotherapeutics 20151202 5
Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, attenuated MV strains preferentially infect and destroy a wide variety of cancer cells making them also attractive oncolytic vectors. The use of recombinant MV vector has to comply with ...[more]
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