Ontology highlight
ABSTRACT:
SUBMITTER: van Steeg TJ
PROVIDER: S-EPMC4966826 | biostudies-other | 2016
REPOSITORIES: biostudies-other
van Steeg Tamara J TJ Bergmann Kirsten Riber KR Dimasi Nazzareno N Sachsenmeier Kris F KF Agoram Balaji B
mAbs 20160224 3
Targeting multiple receptors with bispecific antibodies is a novel approach that may prevent the development of resistance to cancer treatments. Despite the initial promise, full clinical benefit of this technology has yet to be realized. We hypothesized that in order to optimally exploit bispecific antibody technology, thorough fundamental knowledge of their pharmacological properties compared to that of single agent combinations was needed. Therefore, we developed a mathematical model for the ...[more]