Ontology highlight
ABSTRACT:
SUBMITTER: Pawar A
PROVIDER: S-EPMC4973806 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Pawar Archana A Meier Jeremy A JA Dasgupta Anwesha A Diwanji Neha N Deshpande Neha N Saxena Kritika K Buwa Natasha N Inchanalkar Siddhi S Schwartz Martin Alexander MA Balasubramanian Nagaraj N
Cellular signalling 20160604 9
Integrin dependent regulation of growth factor signalling confers anchorage dependence that is deregulated in cancers. Downstream of integrins and oncogenic Ras the small GTPase Ral is a vital mediator of adhesion dependent trafficking and signalling. This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells. In re-adherent mouse fibroblasts (MEFs) integrin dependent activation of RalA drives Arf6 activation. Independent of adhesion constitutivel ...[more]