Ontology highlight
ABSTRACT:
SUBMITTER: Araki M
PROVIDER: S-EPMC4974558 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Araki Makoto M Matsubara Takeshi T Abe Hideharu H Torikoshi Kazuo K Mima Akira A Iehara Noriyuki N Fukatsu Atsushi A Kita Toru T Arai Hidenori H Doi Toshio T
Scientific reports 20160805
Matrix expansion and cell proliferation are concomitantly observed in various glomerular injuries. However, the molecular mechanisms responsible for these changes have not been fully elucidated. We have reported that Smad1 is a key signalling molecule that regulates the transcription of type IV collagen (Col4) in mesangial matrix expansion and is thereby involved in glomerular injury in an acute model of glomerulonephritis. In this study, we addressed the role of Smad1 signalling in accelerated ...[more]