Ontology highlight
ABSTRACT:
SUBMITTER: Kolleth A
PROVIDER: S-EPMC4977289 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Frontiers in chemistry 20160809
We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly, the strategy employed is versatile enough to eventually allow us to complete the synthesis of the nat ...[more]