Ontology highlight
ABSTRACT:
SUBMITTER: Singh H
PROVIDER: S-EPMC4979069 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Singh Himansha H Velamakanni Saroj S Deery Michael J MJ Howard Julie J Wei Shen L SL van Veen Hendrik W HW
Nature communications 20160808
ATP-binding cassette transporters mediate the transbilayer movement of a vast number of substrates in or out of cells in organisms ranging from bacteria to humans. Current alternating access models for ABC exporters including the multidrug and Lipid A transporter MsbA from Escherichia coli suggest a role for nucleotide as the fundamental source of free energy. These models involve cycling between conformations with inward- and outward-facing substrate-binding sites in response to engagement and ...[more]