Ontology highlight
ABSTRACT:
SUBMITTER: Nack WA
PROVIDER: S-EPMC4979757 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Beilstein journal of organic chemistry 20160617
A new palladium-catalyzed picolinamide (PA)-directed ortho-iodination reaction of ε-C(sp(2))-H bonds of γ-arylpropylamine substrates is reported. This reaction proceeds selectively with a variety of γ-arylpropylamines bearing strongly electron-donating or withdrawing substituents, complementing our previously reported PA-directed electrophilic aromatic substitution approach to this transformation. As demonstrated herein, a three step sequence of Pd-catalyzed γ-C(sp(3))-H arylation, Pd-catalyzed ...[more]