Ontology highlight
ABSTRACT:
SUBMITTER: Balez R
PROVIDER: S-EPMC4981845 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Balez Rachelle R Steiner Nicole N Engel Martin M Muñoz Sonia Sanz SS Lum Jeremy Stephen JS Wu Yizhen Y Wang Dadong D Vallotton Pascal P Sachdev Perminder P O'Connor Michael M Sidhu Kuldip K Münch Gerald G Ooi Lezanne L
Scientific reports 20160812
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however a comprehensive assessment has not been performed in a human model of AD. Here we have used a human induced pluripotent stem cell (iPSC) model of familial and sporadic AD, in addit ...[more]