Ontology highlight
ABSTRACT:
SUBMITTER: Matsushita N
PROVIDER: S-EPMC4981851 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Matsushita Nobuko N Suzuki Midori M Ikebe Emi E Nagashima Shun S Inatome Ryoko R Asano Kenichi K Tanaka Masato M Matsushita Masayuki M Kondo Eisaku E Iha Hidekatsu H Yanagi Shigeru S
Scientific reports 20160812
Tax1-binding protein 1 (TAX1BP1) is a ubiquitin-binding protein that restricts nuclear factor-κB (NF-κB) activation and facilitates the termination of aberrant inflammation. However, its roles in B-cell activation and differentiation are poorly understood. To evaluate the function of TAX1BP1 in B cells, we established TAX1BP1-deficient DT40 B cells that are hyper-responsive to CD40-induced extracellular signal-regulated kinase (ERK) activation signaling, exhibit prolonged and exaggerated ERK pho ...[more]