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Gastric biomarkers: a global review.

ABSTRACT: Gastric cancer is an aggressive disease with a poor 5-year survival and large global burden of disease. The disease is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Despite the many prognostic, predictive, and therapeutic biomarkers investigated to date, gastric cancer continues to be detected at an advanced stage with resultant poor clinical outcomes.This is a global review of gastric biomarkers with an emphasis on HER2, E-cadherin, fibroblast growth factor receptor, mammalian target of rapamycin, and hepatocyte growth factor receptor as well as sections on microRNAs, long noncoding RNAs, matrix metalloproteinases, PD-L1, TP53, and microsatellite instability.A deeper understanding of the pathogenesis and biological features of gastric cancer, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers, hopefully will provide improved clinical outcomes.

SUBMITTER: Baniak N

PROVIDER: S-EPMC4982433 | biostudies-other | 2016 Aug

REPOSITORIES: biostudies-other

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Gastric biomarkers: a global review.

Baniak Nick N Senger Jenna-Lynn JL Ahmed Shahid S Kanthan S C SC Kanthan Rani R

World journal of surgical oncology 20160811 1

<h4>Background</h4>Gastric cancer is an aggressive disease with a poor 5-year survival and large global burden of disease. The disease is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Despite the many prognostic, predictive, and therapeutic biomarkers investigated to date, gastric cancer continues to be detected at an advanced stage with resultant poor clinical outcomes.<h4>Main body</h4>This is a global review of gastric biomarkers wi ...[more]

PMID: 27514667

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