Ontology highlight
ABSTRACT:
SUBMITTER: Loskog A
PROVIDER: S-EPMC4984796 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Loskog Angelica A Maleka Aglaia A Mangsbo Sara S Svensson Emma E Lundberg Christina C Nilsson Anders A Krause Johan J Agnarsdóttir Margrét M Sundin Anders A Ahlström Håkan H Tötterman Thomas H TH Ullenhag Gustav G
British journal of cancer 20160331 8
<h4>Background</h4>Current approaches for treating metastatic malignant melanoma (MM) are not effective enough and are associated with serious adverse events. Due to its immunogenicity, melanoma is an attractive target for immunostimulating therapy. In this phase I/IIa study, local AdCD40L immunostimulatory gene therapy was evaluated in patients with MM.<h4>Methods</h4>AdCD40L is an adenovirus carrying the gene for CD40 ligand. Patients that failed standard treatments were enrolled. Six patients ...[more]