Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.
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ABSTRACT:
SUBMITTER: Garcia-Miralles M
PROVIDER: S-EPMC4985819 | biostudies-other | 2016
REPOSITORIES: biostudies-other
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Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.
Garcia-Miralles Marta M Hong Xin X Tan Liang Juin LJ Caron Nicholas S NS Huang Yihui Y To Xuan Vinh XV Lin Rachel Yanping RY Franciosi Sonia S Papapetropoulos Spyros S Hayardeny Liat L Hayden Michael R MR Chuang Kai-Hsiang KH Pouladi Mahmoud A MA
Scientific reports 20160816
Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immunomodulatory agent shown to be protective in a number of neuroinflammatory conditions, in the YAC128 mouse model of HD. Treatment with laquinimod for 6 months rescued atrophy in the striatum, in certain cortical regions, and in the corpus callosum of YAC128 HD mice. Diffusion ten ...[more]
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