Unknown

Dataset Information

0

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.

ABSTRACT: The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

SUBMITTER: Symons J 

PROVIDER: S-EPMC4990826 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.

Symons Jori J   Symons Jori J   Vandekerckhove Linos L   Hütter Gero G   Wensing Annemarie M J AM   van Ham Petra M PM   Deeks Steven G SG   Nijhuis Monique M  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140423 4

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage. ...[more]