Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.
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ABSTRACT:
SUBMITTER: Symons J
PROVIDER: S-EPMC4990826 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
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Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.
Symons Jori J Symons Jori J Vandekerckhove Linos L Hütter Gero G Wensing Annemarie M J AM van Ham Petra M PM Deeks Steven G SG Nijhuis Monique M
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140423 4
The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage. ...[more]
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