Dataset Information

HIV/AIDS epidemic among older adults in China during 2005-2012: results from trend and spatial analysis.

ABSTRACT: Recent studies have indicated an increasing burden of human immunodeficiency virus (HIV)/AIDS among older adults.All identified people living with HIV/AIDS (PLWHA) recorded through the Chinese HIV/AIDS CRS during 2005-2012 were included in the study, except for the cases that lacked specific spatial information. Trend tests and spatial analyses were conducted.Information about 73,521 PLWHA (aged ?50 years) was collected during 2005-2012. Three provinces-Guangxi, Henan, and Yunnan-accounted for 54.4% of the identified cases during the study period. Compared with 2005, the ratio between residents and migrants among the study population decreased to 40.1% in 2012. The ratio of HIV-infected patients to AIDS patients and the ratio of males to females increased gradually among older infected adults. Results of spatial analysis indicate a clustered distribution of HIV/AIDS among older adults throughout the country. Hot spots were observed in 4 provinces (Guangxi, Henan, Yunnan, and Sichuan) and 1 municipality (Chongqing). A trend from central provinces toward southern provinces was also identified.The number and proportion of HIV/AIDS among older adults have increased in recent years. The hot spots showed movement from central to southern China. A focused intervention strategy targeting the older PLWHA is urgently required in China.

SUBMITTER: Xing J

PROVIDER: S-EPMC4990827 | biostudies-other | 2014 Jul

REPOSITORIES: biostudies-other

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HIV/AIDS epidemic among older adults in China during 2005-2012: results from trend and spatial analysis.

Xing Jiannan J Li Yin-ge YG Tang Weiming W Guo Wei W Ding Zhengwei Z Ding Guowei G Wang Liyan L Qin Qianqian Q Xu Yan Y Qian Shasha S Mahapatra Tanmay T Wang Lu L

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140403 2

<h4>Background</h4>Recent studies have indicated an increasing burden of human immunodeficiency virus (HIV)/AIDS among older adults.<h4>Methods</h4>All identified people living with HIV/AIDS (PLWHA) recorded through the Chinese HIV/AIDS CRS during 2005-2012 were included in the study, except for the cases that lacked specific spatial information. Trend tests and spatial analyses were conducted.<h4>Results</h4>Information about 73,521 PLWHA (aged ≥50 years) was collected during 2005-2012. Three p ...[more]

PMID: 24700658

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Project description:BackgroundThe effect of chemical exposure on obesity has raised great concerns. Real-world chemical exposure always imposes mixture impacts, however their exposure patterns and the corresponding associations with obesity have not been fully evaluated.ObjectivesTo discover obesity-related mixed chemical exposure patterns in the general U.S.PopulationMethodsSparse Decompositional Regression (SDR), a model adapted from sparse representation learning technique, was developed to identify exposure patterns of chemical mixtures with exclusion (non-targeted model) and inclusion (targeted model) of health outcomes. We assessed the relationships between the identified chemical mixture patterns and obesity-related indexes. We also conducted a comprehensive evaluation of this SDR model by comparing to the existing models, including generalized linear regression model (GLM), principal component analysis (PCA), and Bayesian kernel machine regression (BKMR).ResultsEight core exposure patterns were identified using the non-targeted SDR model. Patterns of high levels of MEP, high levels of naphthalene metabolites (ΣOH-Nap), and a pattern of high exposure levels of MCOP, MCNP, and MCPP were positively associated with obesity. Patterns of high levels of BP3, and a pattern of higher mixed levels of MPB, PPB, and MEP were found to have negative associations. Associations were strengthened using the targeted SDR model. In the single chemical analysis by GLM, BP3, MBP, PPB, MCOP, and MCNP showed significant associations with obesity or body indexes. The SDR model exceeded the performance of PCA in pattern identification. Both SDR and BKMR identified a positive contribution of ΣOH-Nap and MCOP, as well as a negative contribution of BP3 and PPB to obesity.ConclusionOur study identified five core exposure patterns of chemical mixtures significantly associated with obesity using the newly developed SDR model. The SDR model could open a new avenue for assessing health effects of environmental mixture contaminants.

Dataset Information

HIV/AIDS epidemic among older adults in China during 2005-2012: results from trend and spatial analysis.

Publications

HIV/AIDS epidemic among older adults in China during 2005-2012: results from trend and spatial analysis.

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