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Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives.

ABSTRACT: Three coumarin derivatives, viz. 6-methyl-N-(3-methyl-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO3 (1), N-(3-meth-oxy-phen-yl)-6-methyl-2-oxo-2H-chromene-3-carboxamide, C18H15NO4 (2), and 6-meth-oxy-N-(3-meth-oxy-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO5 (3), were synthesized and structurally characterized. The mol-ecules display intra-molecular N-H?O and weak C-H?O hydrogen bonds, which probably contribute to the approximate planarity of the mol-ecules. The supra-molecular structures feature C-H?O hydrogen bonds and ?-? inter-actions, as confirmed by Hirshfeld surface analyses.

SUBMITTER: Gomes LR

PROVIDER: S-EPMC4992908 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives.

Gomes Lígia R LR Low John Nicolson JN Fonseca André A Matos Maria João MJ Borges Fernanda F

Acta crystallographica. Section E, Crystallographic communications 20160610 Pt 7

Three coumarin derivatives, viz. 6-methyl-N-(3-methyl-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO3 (1), N-(3-meth-oxy-phen-yl)-6-methyl-2-oxo-2H-chromene-3-carboxamide, C18H15NO4 (2), and 6-meth-oxy-N-(3-meth-oxy-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO5 (3), were synthesized and structurally characterized. The mol-ecules display intra-molecular N-H⋯O and weak C-H⋯O hydrogen bonds, which probably contribute to the approximate planarity of the mol-ecules. The supra-molecular stru ...[more]

PMID: 27555933

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