Ontology highlight
ABSTRACT:
SUBMITTER: Shrestha L
PROVIDER: S-EPMC4995156 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Shrestha Liza L Bolaender Alexander A Patel Hardik J HJ Taldone Tony T
Current topics in medicinal chemistry 20160101 25
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells have evolved to co-opt HSP function to promote their own survival. As a result, HSPs such as HSP90 have attracted a great deal of interest as a potential anticancer target. These efforts have resulted in over 20 distinct compounds entering clinical evaluation for the treatment of cancer. However, despite the potent anticancer activity dem ...[more]