Ontology highlight
ABSTRACT:
SUBMITTER: Schenk M
PROVIDER: S-EPMC4995902 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Infection and immunity 20160819 9
The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of interleukin-32 (IL-32), which leads to the differentiation of monocytes into dendritic cells (DC). NOD2 has been implicated in the pathogenesis of human leprosy, yet it is not clear whether Mycobacterium leprae, which has a distinct MDP structure, can acti ...[more]