Ontology highlight
ABSTRACT:
SUBMITTER: Thomsen TT
PROVIDER: S-EPMC4997821 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Thomsen Thomas T TT Mojsoska Biljana B Cruz João C S JC Donadio Stefano S Jenssen Håvard H Løbner-Olesen Anders A Rewitz Kim K
Antimicrobial agents and chemotherapy 20160822 9
We used the fruit fly Drosophila melanogaster as a cost-effective in vivo model to evaluate the efficacy of novel antibacterial peptides and peptoids for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. A panel of peptides with known antibacterial activity in vitro and/or in vivo was tested in Drosophila Although most peptides and peptoids that were effective in vitro failed to rescue lethal effects of S. aureus infections in vivo, we found that two lantibiotics, nisin ...[more]