ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.
Ontology highlight
ABSTRACT:
SUBMITTER: Drolez A
PROVIDER: S-EPMC5000706 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Publications
ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.
Drolez Aurore A Vandenhaute Elodie E Delannoy Clément Philippe CP Dewald Justine Hélène JH Gosselet Fabien F Cecchelli Romeo R Julien Sylvain S Dehouck Marie-Pierre MP Delannoy Philippe P Mysiorek Caroline C
International journal of molecular sciences 20160811 8
The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34⁺ derived endothelial cells co-cultivated with p ...[more]
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