ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.

ABSTRACT: The ST6GALNAC5 gene that encodes an ?2,6-sialyltransferase involved in the biosynthesis of ?-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1? ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34? derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.

SUBMITTER: Drolez A 

PROVIDER: S-EPMC5000706 | biostudies-other | 2016 Aug

REPOSITORIES: biostudies-other