Ontology highlight
ABSTRACT:
SUBMITTER: Rajakumar S
PROVIDER: S-EPMC5003806 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Rajakumar Selvaraj S Bhanupriya Nagaraj N Ravi Chidambaram C Nachiappan Vasanthi V
Cell stress & chaperones 20160625 5
The endoplasmic reticulum is the key organelle which controls protein folding, lipid biogenesis, and calcium (Ca(2+)) homeostasis. Cd exposure in Saccharomyces cerevisiae activated the unfolded protein response and was confirmed by the increased Kar2p expression. Cd exposure in wild-type (WT) cells increased PC levels and the PC biosynthetic genes. Deletion of the two phospholipid methyltransferases CHO2 and OPI3 modulated PC, TAG levels and the lipid droplets with cadmium exposure. Interestingl ...[more]