Ontology highlight
ABSTRACT:
SUBMITTER: Nagy M
PROVIDER: S-EPMC50045 | biostudies-other | 1992 Oct
REPOSITORIES: biostudies-other
Nagy M M Lacroute F F Thomas D D
Proceedings of the National Academy of Sciences of the United States of America 19921001 19
A cDNA encoding the dihydroorotate dehydrogenase (DHOdehase; EC 1.3.3.1) of the yeast Schizosaccharomyces pombe was isolated by functional complementation in Saccharomyces cerevisiae. A divergent subcellular compartmentation of the DHOdehase of each yeast was shown. The DHOdehase from Sch. pombe was localized in the mitochondria whereas its homolog from S. cerevisiae was found to be cytosolic. The heterologous expression of the Sch. pombe enzyme in S. cerevisiae allowed us to demonstrate that th ...[more]