Bioactive extracellular matrix fragments in lung health and disease.
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ABSTRACT:
SUBMITTER: Gaggar A
PROVIDER: S-EPMC5004953 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Publications
Bioactive extracellular matrix fragments in lung health and disease.
Gaggar Amit A Weathington Nathaniel N
The Journal of clinical investigation 20160901 9
The extracellular matrix (ECM) is the noncellular component critical in the maintenance of organ structure and the regulation of tissue development, organ structure, and cellular signaling. The ECM is a dynamic entity that undergoes continuous degradation and resynthesis. In addition to compromising structure, degradation of the ECM can liberate bioactive fragments that cause cellular activation and chemotaxis of a variety of cells. These fragments are termed matrikines, and their cellular activ ...[more]
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