Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5006031 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Xu Yongjie Y Bian Xintong X Sang Ye Y Li Yujian Y Li Dandan D Cheng Wei W Yin Yibing Y Ju Huangxian H Ding Shijia S
Scientific reports 20160831
A novel G-quadruplex DNAzyme-driven chemiluminescence (CL) imaging method has been developed for ultrasensitive and specific detection of BCR/ABL fusion gene based on bis-three-way junction (bis-3WJ) nanostructure and cascade DNA machineries. Bis-3WJ probes are designed logically to recognize BCR/ABL fusion gene, which forms the stable bis-3WJ nanostructure for the activation of polymerase/nicking enzyme machineries in cascade, resulting in synthesis of DNAzyme subunits. These DNAzyme subunits c ...[more]