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Vaccines for Healthcare-associated Infections: Promise and Challenge.

ABSTRACT: As antibiotic resistance increases and the rate of antibiotic development slows, it is becoming more urgent to develop novel approaches to prevent and mitigate serious bacterial and fungal infections. Healthcare-associated infections (HAIs), including those caused by Clostridium difficile, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, carbapenem-resistant Enterobacteriaceae, and Candida species, are a major cause of morbidity, mortality, and healthcare costs. HAIs are also a key driver of antibiotic use. Vaccines directed toward these pathogens could help prevent a large number of HAIs and associated antibiotic use if administered to targeted populations. Despite numerous scientific and operational challenges, there are vaccine candidates in late-stage clinical development for C. difficile, S. aureus, and P. aeruginosa Basic, preclinical, and early clinical research to develop vaccines for other types of HAIs is also under way. In addition, other prophylactic immune interventions, such as monoclonal antibodies, for several of these pathogens are in advanced development. Here we describe the promise, challenges, and current pipeline of vaccines to prevent HAIs.

SUBMITTER: Knisely JM

PROVIDER: S-EPMC5006206 | biostudies-other | 2016 Sep

REPOSITORIES: biostudies-other

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Vaccines for Healthcare-associated Infections: Promise and Challenge.

Knisely Jane M JM Liu Baoying B Ranallo Ryan T RT Zou Lanling L

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20160520 5

As antibiotic resistance increases and the rate of antibiotic development slows, it is becoming more urgent to develop novel approaches to prevent and mitigate serious bacterial and fungal infections. Healthcare-associated infections (HAIs), including those caused by Clostridium difficile, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, carbapenem-resistant Enterobacteriaceae, and Candida species, are a major cause of morbidity, mortality, and healthcare costs. HAIs are a ...[more]

PMID: 27208045

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Dataset Information

Vaccines for Healthcare-associated Infections: Promise and Challenge.

Publications

Vaccines for Healthcare-associated Infections: Promise and Challenge.

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