Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC5007298 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Nature communications 20160825
Construction of two vicinal all-carbon quaternary carbon centres is of great importance due to the common presence of such units in natural and unnatural molecules with attractive functions. However, it remains a significant challenge. Here, we have developed a palladium-catalysed general coupling for the efficient connection of two tertiary carbon atoms: Specifically, propargylic carbonate has been treated with a fully loaded soft functionalized nucleophile to connect such two fully loaded carb ...[more]