Ontology highlight
ABSTRACT:
SUBMITTER: Hieber SE
PROVIDER: S-EPMC5007499 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Hieber Simone E SE Bikis Christos C Khimchenko Anna A Schweighauser Gabriel G Hench Jürgen J Chicherova Natalia N Schulz Georg G Müller Bert B
Scientific reports 20160901
Brain tissue evaluation is essential for gaining in-depth insight into its diseases and disorders. Imaging the human brain in three dimensions has always been a challenge on the cell level. In vivo methods lack spatial resolution, and optical microscopy has a limited penetration depth. Herein, we show that hard X-ray phase tomography can visualise a volume of up to 43 mm(3) of human post mortem or biopsy brain samples, by demonstrating the method on the cerebellum. We automatically identified 5, ...[more]