Identification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma.
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ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC5008307 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Publications
Identification of a six microRNA signature as a novel potential prognostic biomarker in patients with head and neck squamous cell carcinoma.
Shi Hao H Chen Jian J Li Yuncheng Y Li Guojun G Zhong Rong R Du Dandan D Meng Ruiwei R Kong Weijia W Lu Meixia M
Oncotarget 20160401 16
The 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) was only 40%-50%. To investigate the prognostic and predictive value of specific mircoRNAs (miRNAs) in HNSCC. We identified 19 miRNAs associated with over survival (OS) of patients with HNSCC in different clinical classes between 492 HNSCC tissues and 44 normal tissues from The Cancer Genome Atlas (TCGA) dataset. A signature of six miRNAs was identified by the supervised principal component method in the trai ...[more]
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