Ontology highlight
ABSTRACT:
SUBMITTER: Mingozzi F
PROVIDER: S-EPMC5009809 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Mingozzi Francesca F Spreafico Roberto R Gorletta Tatiana T Cigni Clara C Di Gioia Marco M Caccia Michele M Sironi Laura L Collini Maddalena M Soncini Matias M Rusconi Michela M von Andrian Ulrich H UH Chirico Giuseppe G Zanoni Ivan I Granucci Francesca F
EMBO molecular medicine 20160901 9
Natural killer (NK) cells are critical players against tumors. The outcome of anti-tumor vaccination protocols depends on the efficiency of NK-cell activation, and efforts are constantly made to manipulate them for immunotherapeutic approaches. Thus, a better understanding of NK-cell activation dynamics is needed. NK-cell interactions with accessory cells and trafficking between secondary lymphoid organs and tumoral tissues remain poorly characterized. Here, we show that upon triggering innate i ...[more]