Ontology highlight
ABSTRACT:
SUBMITTER: Kruizinga RC
PROVIDER: S-EPMC5010837 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Kruizinga Roeliene C RC van Marion Denise M S DM den Dunnen Wilfred F A WF de Groot Jan C JC Hoving Eelco W EW Oosting Sjoukje F SF Timmer-Bosscha Hetty H Derks Rosalie P H RP Cornelissen Chantal C van der Luijt Rob B RB Links Thera P TP de Vries Elisabeth G E EG Walenkamp Annemiek M E AM
Familial cancer 20161001 4
Central nervous system hemangioblastomas occur sporadically and in patients with von Hippel-Lindau (VHL) disease due to a VHL germline mutation. This mutation leads to enhanced transcription of chemokine receptor 4 (CXCR4), its ligand (CXCL12) and vascular endothelial growth factor A (VEGFA). We aimed to determine in VHL-related and sporadic hemangioblastomas CXCR4, CXCL12, and VEGFA protein expression and to correlate this to hemangioblastoma size and expression in normal surrounding tissue. 27 ...[more]