Ontology highlight
ABSTRACT:
SUBMITTER: Uno N
PROVIDER: S-EPMC5014537 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Uno Narumi N Uno Katsuhiro K Komoto Shinya S Suzuki Teruhiko T Hiratsuka Masaharu M Osaki Mitsuhiko M Kazuki Yasuhiro Y Oshimura Mitsuo M
Molecular therapy. Nucleic acids 20151215
The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability. Here, we attempted to develop a tumor-suppressing mammalian artificial chromosome containing a safeguard system that uses the immune rejection system against allogeneic tissue from the host. For pro ...[more]