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How we treat bleeding associated with direct oral anticoagulants.


ABSTRACT: Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow better and safer management of the rapid reversal of their anticoagulant effect.

SUBMITTER: Marano G 

PROVIDER: S-EPMC5016308 | biostudies-other | 2016 Sep

REPOSITORIES: biostudies-other

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How we treat bleeding associated with direct oral anticoagulants.

Marano Giuseppe G   Vaglio Stefania S   Pupella Simonetta S   Liumbruno Giancarlo M GM   Franchini Massimo M  

Blood transfusion = Trasfusione del sangue 20160119 5


Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow bette  ...[more]

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