Dataset Information

Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

ABSTRACT: While low vitamin K status has been associated with several chronic diseases that can lead to lower extremity disability, it is not known if low vitamin K status is associated with worse lower extremity function.Vitamin K status was measured according to plasma phylloquinone (vitamin K1) and dephosphorylated-uncarboxylated MGP (dp-ucMGP) in 1,089 community-dwelling older adults (mean ± SD age =74±3 years; 67% female). Lower extremity function was assessed using the short physical performance battery (SPPB), gait speed, and isokinetic leg strength. Linear regression and mixed models were used to determine the cross-sectional and longitudinal associations between vitamin K status and functional outcome measures.Cross-sectionally, higher plasma phylloquinone was associated with better SPPB scores and 20-m gait speed (p ? .05). After 4-5 years, those with ?1.0nM plasma phylloquinone (the concentration achieved when recommended intakes are met) had better SPPB scores (p = .03) and 20-m gait speed (p < .05). Lower plasma dp-ucMGP (reflective of better vitamin K status) was associated with better SPPB scores and leg strength cross-sectionally (p ? .04), but not longitudinally. Neither measure of vitamin K status was associated with walking endurance or with the rate of decline in function.Older adults with higher vitamin K status had better physical performance scores at baseline, but data are less consistent longitudinally. Since lower extremity disability is a common consequence of multiple chronic diseases for which a role of vitamin K has been suggested, future studies are needed to determine if vitamin K supplementation could improve function in those with vitamin K insufficiency and clarify underlying mechanism(s).

SUBMITTER: Shea MK

PROVIDER: S-EPMC5018560 | biostudies-other | 2016 Oct

REPOSITORIES: biostudies-other

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Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

Shea M Kyla MK Loeser Richard F RF Hsu Fang-Chi FC Booth Sarah L SL Nevitt Michael M Simonsick Eleanor M EM Strotmeyer Elsa S ES Vermeer Cees C Kritchevsky Stephen B SB

The journals of gerontology. Series A, Biological sciences and medical sciences 20151117 10

<h4>Background</h4>While low vitamin K status has been associated with several chronic diseases that can lead to lower extremity disability, it is not known if low vitamin K status is associated with worse lower extremity function.<h4>Methods</h4>Vitamin K status was measured according to plasma phylloquinone (vitamin K1) and dephosphorylated-uncarboxylated MGP (dp-ucMGP) in 1,089 community-dwelling older adults (mean ± SD age =74±3 years; 67% female). Lower extremity function was assessed using ...[more]

PMID: 26576842

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Project description:BackgroundLower muscle and higher fat mass are characteristics of older adults; their physical function is also characterized by slower gait speed and weaker strength. However, the association between specific body composition and physical function is unclear.MethodsWe examined the association between body composition and physical performance using combined cross-sectional data of 1,821 participants from 13 clinical studies at Wake Forest University that used a consistent battery of tests. All participants were ≥60 years old and had one of the following conditions: healthy, osteoarthritis, coronary artery disease, obesity, heart failure, at elevated risk for disability, renal transplantation candidates, heart failure with preserved ejection fraction, moderate self-reported disability, hypertension, diabetes, or coronary artery disease, at high risk for cardiovascular disease. Data at enrollment from each study using uniform tools including body mass index (BMI), dual energy x-ray absorptiometry, physical performance assessment using 4 m walk speed, five chair rise time, handgrip strength, short physical performance battery (17), and Pepper Assessment Tool for Disability were analyzed.ResultsIncreased BMI was associated with slower walk speed, lower short physical performance battery, and higher Pepper Assessment Tool for Disability score. Increased percentage of body fat was associated with slower walk speed, lower hand grip strength, lower short physical performance battery scores, and higher Pepper Assessment Tool for Disability scores. Percent appendicular lean mass was associated with faster walk speed, higher handgrip strength, higher short physical performance battery, and lower Pepper Assessment Tool for Disability score. There were no significant discrepancies in relationship between body composition and physical function by gender except gender and BMI on chair-rise time.ConclusionsHigher BMI and percent body fat were associated with poor physical function while percent appendicular lean mass was associated with better physical function. There was no significant discrepancy in the by gender.

Dataset Information

Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

Publications

Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

Similar Datasets

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