Ontology highlight
ABSTRACT:
SUBMITTER: Ulges A
PROVIDER: S-EPMC5018788 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Ulges Alexander A Witsch Esther J EJ Pramanik Gautam G Klein Matthias M Birkner Katharina K Bühler Ulrike U Wasser Beatrice B Luessi Felix F Stergiou Natascha N Dietzen Sarah S Brühl Till-Julius TJ Bohn Toszka T Bündgen Georg G Kunz Horst H Waisman Ari A Schild Hansjörg H Schmitt Edgar E Zipp Frauke F Bopp Tobias T
Proceedings of the National Academy of Sciences of the United States of America 20160823 36
T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to be pivotal in the maintenance of peripheral tolerance. Thus, the balance between Treg cells and TH17 cells determines the severity of a TH17 cell-driven disease and therefore is a pr ...[more]