Ontology highlight
ABSTRACT:
SUBMITTER: Evans CA
PROVIDER: S-EPMC5018865 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20160722 9
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors. ...[more]