Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.
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ABSTRACT:
SUBMITTER: Johnston NR
PROVIDER: S-EPMC5031557 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Publications
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.
Johnston Natalie R NR Mitchell Ryan K RK Haythorne Elizabeth E Pessoa Maria Paiva MP Semplici Francesca F Ferrer Jorge J Piemonti Lorenzo L Marchetti Piero P Bugliani Marco M Bosco Domenico D Berishvili Ekaterine E Duncanson Philip P Watkinson Michael M Broichhagen Johannes J Trauner Dirk D Rutter Guy A GA Hodson David J DJ
Cell metabolism 20160721 3
The arrangement of β cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for individual β cells in orchestrating these responses has long been suspected, but not directly demonstrated. We show here that the β cell population in situ is operationally heterogeneous. Mapping of islet functional architecture revealed the presence of hub cells with pacemaker properties, which remain stable over recording periods of 2 to 3 hr ...[more]
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