Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad I
PROVIDER: S-EPMC50318 | biostudies-other | 1992 Nov
REPOSITORIES: biostudies-other
Ahmad I I Korbmacher C C Segal A S AS Cheung P P Boulpaep E L EL Barnstable C J CJ
Proceedings of the National Academy of Sciences of the United States of America 19921101 21
Apical nonselective cation channels with an average single-channel conductance of 34 +/- 2.3 pS were found in M-1 mouse cortical collecting duct cells. Channel activity is increased by depolarization and abolished by cytoplasmic calcium removal. Cytoplasmic application of 0.1 mM cGMP decreases channel open probability by 27%. cDNAs corresponding to approximately 40% of the coding region of the photoreceptor channel were isolated by the polymerase chain reaction from M-1 cells and a rat kidney cD ...[more]