Ontology highlight
ABSTRACT:
SUBMITTER: Courtheoux T
PROVIDER: S-EPMC5031805 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Courtheoux Thibault T Enchev Radoslav I RI Lampert Fabienne F Gerez Juan J Beck Jochen J Picotti Paola P Sumara Izabela I Peter Matthias M
Nature communications 20160919
Directed cell movement involves spatial and temporal regulation of the cortical microtubule (Mt) and actin networks to allow focal adhesions (FAs) to assemble at the cell front and disassemble at the rear. Mts are known to associate with FAs, but the mechanisms coordinating their dynamic interactions remain unknown. Here we show that the CRL3(KLHL21) E3 ubiquitin ligase promotes cell migration by controlling Mt and FA dynamics at the cell cortex. Indeed, KLHL21 localizes to FA structures prefere ...[more]