Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.
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ABSTRACT:
SUBMITTER: Castillo-Acosta VM
PROVIDER: S-EPMC5035034 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Publications
Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.
Castillo-Acosta Víctor M VM Ruiz-Pérez Luis M LM Etxebarria Juan J Reichardt Niels C NC Navarro Miguel M Igarashi Yasuhiro Y Liekens Sandra S Balzarini Jan J González-Pacanowska Dolores D
PLoS pathogens 20160923 9
Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles. Here, we report a new approach to address treatment of this disease based on the use of compounds that bind to parasite surface glycans leading to rapid killing of trypanosomes. Pradimicin and its derivatives are non-peptidic carbohydrate-binding agents that adhere to the carbohydrate moiety of the parasite surface glycoproteins induc ...[more]
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