Ontology highlight
ABSTRACT:
SUBMITTER: Rudnizky S
PROVIDER: S-EPMC5036153 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Rudnizky Sergei S Bavly Adaiah A Malik Omri O Pnueli Lilach L Melamed Philippa P Kaplan Ariel A
Nature communications 20160922
The structure and dynamics of promoter chromatin have a profound effect on the expression levels of genes. Yet, the contribution of DNA sequence, histone post-translational modifications, histone variant usage and other factors in shaping the architecture of chromatin, and the mechanisms by which this architecture modulates expression of specific genes are not yet completely understood. Here we use optical tweezers to study the roles that DNA sequence and the histone variant H2A.Z have in shapin ...[more]