Ontology highlight
ABSTRACT:
SUBMITTER: Xie H
PROVIDER: S-EPMC5042007 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Xie Huijun H Ren Xiaoli X Xin Sainan S Lan Xiaoliang X Lu Guifeng G Lin Yuan Y Yang Shaoshan S Zeng Zhicheng Z Liao Wenting W Ding Yan-Qing YQ Liang Li L
Oncotarget 20160501 18
Circular RNAs (circRNAs), a large class of RNAs, have recently shown huge capabilities as gene regulators in mammals. Some of them bind with microRNAs (miRNAs) and act as natural miRNA sponges to inhibit related miRNAs' activities. Here we showed that hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC ti ...[more]