Ontology highlight
ABSTRACT:
SUBMITTER: Regina C
PROVIDER: S-EPMC5045360 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Regina Carla C Compagnone Mirco M Peschiaroli Angelo A Lena AnnaMaria A Annicchiarico-Petruzzelli Margherita M Piro Maria Cristina MC Melino Gerry G Candi Eleonora E
Oncotarget 20160501 20
ΔNp63 has been recently involved in self-renewal potential of breast cancer stem cells. Although the p63 transcriptional profile has been extensively characterized, our knowledge of the p63-binding partners potentially involved in the regulation of breast tumour progression is limited. Here, we performed the yeast two hybrid approach to identify p63α interactors involved in breast tumorigenesis and we found that SETDB1, a histone lysine methyl transferases, interacts with ΔNp63α and that this in ...[more]