Ontology highlight
ABSTRACT:
SUBMITTER: Bhatt K
PROVIDER: S-EPMC5048147 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Scientific reports 20161004
Induction of cathelicidin-mediated antimicrobial pathway against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), the active form of vitamin D, has been documented in vitro. However, in in vivo studies related to inflammatory disorders, 1,25(OH)<sub>2</sub>D<sub>3</sub> has been demonstrated to induce an anti-inflammatory response. We therefore examined whether in the murine model of tuberculosis, the anti-inflammatory effects of 1,25(OH)< ...[more]