Ontology highlight
ABSTRACT:
SUBMITTER: Ozes AR
PROVIDER: S-EPMC5050052 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Özeş A R AR Miller D F DF Özeş O N ON Fang F F Liu Y Y Matei D D Huang T T Nephew K P KP
Oncogene 20160404 41
The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recurrent platinum-resistant ovarian tumors vs primary ovarian tumors. To investigate the role of HOTAIR during DNA damage induced by platinum, we monitored double-strand breaks and sho ...[more]