Ontology highlight
ABSTRACT:
SUBMITTER: Kolb I
PROVIDER: S-EPMC5057089 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Kolb I I Stoy W A WA Rousseau E B EB Moody O A OA Jenkins A A Forest C R CR
Scientific reports 20161011
Patch-clamp recording has enabled single-cell electrical, morphological and genetic studies at unparalleled resolution. Yet it remains a laborious and low-throughput technique, making it largely impractical for large-scale measurements such as cell type and connectivity characterization of neurons in the brain. Specifically, the technique is critically limited by the ubiquitous practice of manually replacing patch-clamp pipettes after each recording. To circumvent this limitation, we developed a ...[more]